Dr. David Eisenstat
Dr. Eisenstat’s research involves understanding the regulation of cell growth and differentiation during development. Biological response modifiers have been used to treat several types of malignancy by harnessing normal developmental programs specific to these relatively undifferentiated cancer cell populations. The aim is to facilitate understanding of the processes of cell differentiation through improved understanding of two important regulatory molecules: (i) hypoxia-inducible cell death protein, BNIP3 (ii) the DLX homeodomain proteins. Ultimately, they hope to develop novel therapeutic approaches by modifying neuronal differentiation programs in paediatric malignancies.
